Increased inflammatory signaling and lethality of influenza H1N1 by nuclear thioredoxin-1.
Identifieur interne : 001540 ( Main/Exploration ); précédent : 001539; suivant : 001541Increased inflammatory signaling and lethality of influenza H1N1 by nuclear thioredoxin-1.
Auteurs : Young-Mi Go [États-Unis] ; Sang-Moo Kang ; James R. Roede ; Michael Orr ; Dean P. JonesSource :
- PloS one [ 1932-6203 ] ; 2011.
Descripteurs français
- KwdFr :
- ARN messager (génétique), ARN messager (métabolisme), Animaux, Antioxydants (métabolisme), Apoptose (), Cytokines (métabolisme), Disulfure de glutathion (sang), Facteur de transcription NF-kappa B (métabolisme), Glucocorticoïdes (pharmacologie), Grippe humaine (), Grippe humaine (mortalité), Grippe humaine (métabolisme), Grippe humaine (virologie), Humains, Infections à Orthomyxoviridae (), Infections à Orthomyxoviridae (anatomopathologie), Infections à Orthomyxoviridae (mortalité), Infections à Orthomyxoviridae (virologie), Inflammation (), Inflammation (anatomopathologie), Noyau de la cellule (), Noyau de la cellule (métabolisme), Oxydoréduction (), Perte de poids, Régulation de l'expression des gènes (), Signaux de localisation nucléaire (métabolisme), Souris, Souris de lignée C57BL, Souris transgéniques, Sous-type H1N1 du virus de la grippe A (), Sous-type H1N1 du virus de la grippe A (physiologie), Thiorédoxines (génétique), Thiorédoxines (métabolisme), Transduction du signal (), Transport de protéines ().
- MESH :
- anatomopathologie : Infections à Orthomyxoviridae, Inflammation.
- génétique : ARN messager, Thiorédoxines.
- mortalité : Grippe humaine, Infections à Orthomyxoviridae.
- métabolisme : ARN messager, Antioxydants, Cytokines, Facteur de transcription NF-kappa B, Grippe humaine, Noyau de la cellule, Signaux de localisation nucléaire, Thiorédoxines.
- pharmacologie : Glucocorticoïdes.
- physiologie : Sous-type H1N1 du virus de la grippe A.
- sang : Disulfure de glutathion.
- virologie : Grippe humaine, Infections à Orthomyxoviridae.
- Animaux, Apoptose, Grippe humaine, Humains, Infections à Orthomyxoviridae, Inflammation, Noyau de la cellule, Oxydoréduction, Perte de poids, Régulation de l'expression des gènes, Souris, Souris de lignée C57BL, Souris transgéniques, Sous-type H1N1 du virus de la grippe A, Transduction du signal, Transport de protéines.
English descriptors
- KwdEn :
- Animals, Antioxidants (metabolism), Apoptosis (drug effects), Cell Nucleus (drug effects), Cell Nucleus (metabolism), Cytokines (metabolism), Gene Expression Regulation (drug effects), Glucocorticoids (pharmacology), Glutathione Disulfide (blood), Humans, Inflammation (complications), Inflammation (pathology), Influenza A Virus, H1N1 Subtype (drug effects), Influenza A Virus, H1N1 Subtype (physiology), Influenza, Human (complications), Influenza, Human (metabolism), Influenza, Human (mortality), Influenza, Human (virology), Mice, Mice, Inbred C57BL, Mice, Transgenic, NF-kappa B (metabolism), Nuclear Localization Signals (metabolism), Orthomyxoviridae Infections (complications), Orthomyxoviridae Infections (mortality), Orthomyxoviridae Infections (pathology), Orthomyxoviridae Infections (virology), Oxidation-Reduction (drug effects), Protein Transport (drug effects), RNA, Messenger (genetics), RNA, Messenger (metabolism), Signal Transduction (drug effects), Thioredoxins (genetics), Thioredoxins (metabolism), Weight Loss.
- MESH :
- chemical , blood : Glutathione Disulfide.
- chemical , genetics : RNA, Messenger, Thioredoxins.
- chemical , metabolism : Antioxidants, Cytokines, NF-kappa B, Nuclear Localization Signals, RNA, Messenger, Thioredoxins.
- complications : Inflammation, Influenza, Human, Orthomyxoviridae Infections.
- drug effects : Apoptosis, Cell Nucleus, Gene Expression Regulation, Influenza A Virus, H1N1 Subtype, Oxidation-Reduction, Protein Transport, Signal Transduction.
- metabolism : Cell Nucleus, Influenza, Human.
- mortality : Influenza, Human, Orthomyxoviridae Infections.
- pathology : Inflammation, Orthomyxoviridae Infections.
- chemical , pharmacology : Glucocorticoids.
- physiology : Influenza A Virus, H1N1 Subtype.
- virology : Influenza, Human, Orthomyxoviridae Infections.
- Animals, Humans, Mice, Mice, Inbred C57BL, Mice, Transgenic, Weight Loss.
Abstract
Cell culture studies show that the antioxidant thiol protein, thioredoxin-1 (Trx1), translocates to cell nuclei during stress, facilitates DNA binding of transcription factors NF-κB and glucocorticoid receptor (GR) and potentiates signaling in immune cells. Excessive proinflammatory signaling in vivo contributes to immune hyper-responsiveness and disease severity, but no studies have addressed whether nuclear Trx1 mediates such responses.
DOI: 10.1371/journal.pone.0018918
PubMed: 21526215
Affiliations:
Links toward previous steps (curation, corpus...)
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Le document en format XML
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<author><name sortKey="Go, Young Mi" sort="Go, Young Mi" uniqKey="Go Y" first="Young-Mi" last="Go">Young-Mi Go</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, Georgia, United States of America.</nlm:affiliation>
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<author><name sortKey="Kang, Sang Moo" sort="Kang, Sang Moo" uniqKey="Kang S" first="Sang-Moo" last="Kang">Sang-Moo Kang</name>
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<author><name sortKey="Roede, James R" sort="Roede, James R" uniqKey="Roede J" first="James R" last="Roede">James R. Roede</name>
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<author><name sortKey="Orr, Michael" sort="Orr, Michael" uniqKey="Orr M" first="Michael" last="Orr">Michael Orr</name>
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<author><name sortKey="Jones, Dean P" sort="Jones, Dean P" uniqKey="Jones D" first="Dean P" last="Jones">Dean P. Jones</name>
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<term>Antioxidants (metabolism)</term>
<term>Apoptosis (drug effects)</term>
<term>Cell Nucleus (drug effects)</term>
<term>Cell Nucleus (metabolism)</term>
<term>Cytokines (metabolism)</term>
<term>Gene Expression Regulation (drug effects)</term>
<term>Glucocorticoids (pharmacology)</term>
<term>Glutathione Disulfide (blood)</term>
<term>Humans</term>
<term>Inflammation (complications)</term>
<term>Inflammation (pathology)</term>
<term>Influenza A Virus, H1N1 Subtype (drug effects)</term>
<term>Influenza A Virus, H1N1 Subtype (physiology)</term>
<term>Influenza, Human (complications)</term>
<term>Influenza, Human (metabolism)</term>
<term>Influenza, Human (mortality)</term>
<term>Influenza, Human (virology)</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Transgenic</term>
<term>NF-kappa B (metabolism)</term>
<term>Nuclear Localization Signals (metabolism)</term>
<term>Orthomyxoviridae Infections (complications)</term>
<term>Orthomyxoviridae Infections (mortality)</term>
<term>Orthomyxoviridae Infections (pathology)</term>
<term>Orthomyxoviridae Infections (virology)</term>
<term>Oxidation-Reduction (drug effects)</term>
<term>Protein Transport (drug effects)</term>
<term>RNA, Messenger (genetics)</term>
<term>RNA, Messenger (metabolism)</term>
<term>Signal Transduction (drug effects)</term>
<term>Thioredoxins (genetics)</term>
<term>Thioredoxins (metabolism)</term>
<term>Weight Loss</term>
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<term>ARN messager (métabolisme)</term>
<term>Animaux</term>
<term>Antioxydants (métabolisme)</term>
<term>Apoptose ()</term>
<term>Cytokines (métabolisme)</term>
<term>Disulfure de glutathion (sang)</term>
<term>Facteur de transcription NF-kappa B (métabolisme)</term>
<term>Glucocorticoïdes (pharmacologie)</term>
<term>Grippe humaine ()</term>
<term>Grippe humaine (mortalité)</term>
<term>Grippe humaine (métabolisme)</term>
<term>Grippe humaine (virologie)</term>
<term>Humains</term>
<term>Infections à Orthomyxoviridae ()</term>
<term>Infections à Orthomyxoviridae (anatomopathologie)</term>
<term>Infections à Orthomyxoviridae (mortalité)</term>
<term>Infections à Orthomyxoviridae (virologie)</term>
<term>Inflammation ()</term>
<term>Inflammation (anatomopathologie)</term>
<term>Noyau de la cellule ()</term>
<term>Noyau de la cellule (métabolisme)</term>
<term>Oxydoréduction ()</term>
<term>Perte de poids</term>
<term>Régulation de l'expression des gènes ()</term>
<term>Signaux de localisation nucléaire (métabolisme)</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Souris transgéniques</term>
<term>Sous-type H1N1 du virus de la grippe A ()</term>
<term>Sous-type H1N1 du virus de la grippe A (physiologie)</term>
<term>Thiorédoxines (génétique)</term>
<term>Thiorédoxines (métabolisme)</term>
<term>Transduction du signal ()</term>
<term>Transport de protéines ()</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Glutathione Disulfide</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA, Messenger</term>
<term>Thioredoxins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antioxidants</term>
<term>Cytokines</term>
<term>NF-kappa B</term>
<term>Nuclear Localization Signals</term>
<term>RNA, Messenger</term>
<term>Thioredoxins</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Infections à Orthomyxoviridae</term>
<term>Inflammation</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Inflammation</term>
<term>Influenza, Human</term>
<term>Orthomyxoviridae Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Apoptosis</term>
<term>Cell Nucleus</term>
<term>Gene Expression Regulation</term>
<term>Influenza A Virus, H1N1 Subtype</term>
<term>Oxidation-Reduction</term>
<term>Protein Transport</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN messager</term>
<term>Thiorédoxines</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cell Nucleus</term>
<term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Influenza, Human</term>
<term>Orthomyxoviridae Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Grippe humaine</term>
<term>Infections à Orthomyxoviridae</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ARN messager</term>
<term>Antioxydants</term>
<term>Cytokines</term>
<term>Facteur de transcription NF-kappa B</term>
<term>Grippe humaine</term>
<term>Noyau de la cellule</term>
<term>Signaux de localisation nucléaire</term>
<term>Thiorédoxines</term>
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<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Inflammation</term>
<term>Orthomyxoviridae Infections</term>
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<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Glucocorticoids</term>
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<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term>
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<term>Infections à Orthomyxoviridae</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term>
<term>Orthomyxoviridae Infections</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Humans</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Transgenic</term>
<term>Weight Loss</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Apoptose</term>
<term>Grippe humaine</term>
<term>Humains</term>
<term>Infections à Orthomyxoviridae</term>
<term>Inflammation</term>
<term>Noyau de la cellule</term>
<term>Oxydoréduction</term>
<term>Perte de poids</term>
<term>Régulation de l'expression des gènes</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Souris transgéniques</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Transduction du signal</term>
<term>Transport de protéines</term>
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<front><div type="abstract" xml:lang="en">Cell culture studies show that the antioxidant thiol protein, thioredoxin-1 (Trx1), translocates to cell nuclei during stress, facilitates DNA binding of transcription factors NF-κB and glucocorticoid receptor (GR) and potentiates signaling in immune cells. Excessive proinflammatory signaling in vivo contributes to immune hyper-responsiveness and disease severity, but no studies have addressed whether nuclear Trx1 mediates such responses.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Géorgie (États-Unis)</li>
</region>
</list>
<tree><noCountry><name sortKey="Jones, Dean P" sort="Jones, Dean P" uniqKey="Jones D" first="Dean P" last="Jones">Dean P. Jones</name>
<name sortKey="Kang, Sang Moo" sort="Kang, Sang Moo" uniqKey="Kang S" first="Sang-Moo" last="Kang">Sang-Moo Kang</name>
<name sortKey="Orr, Michael" sort="Orr, Michael" uniqKey="Orr M" first="Michael" last="Orr">Michael Orr</name>
<name sortKey="Roede, James R" sort="Roede, James R" uniqKey="Roede J" first="James R" last="Roede">James R. Roede</name>
</noCountry>
<country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Go, Young Mi" sort="Go, Young Mi" uniqKey="Go Y" first="Young-Mi" last="Go">Young-Mi Go</name>
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</record>
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