Serveur d'exploration Stress et Covid

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Increased inflammatory signaling and lethality of influenza H1N1 by nuclear thioredoxin-1.

Identifieur interne : 001540 ( Main/Exploration ); précédent : 001539; suivant : 001541

Increased inflammatory signaling and lethality of influenza H1N1 by nuclear thioredoxin-1.

Auteurs : Young-Mi Go [États-Unis] ; Sang-Moo Kang ; James R. Roede ; Michael Orr ; Dean P. Jones

Source :

RBID : pubmed:21526215

Descripteurs français

English descriptors

Abstract

Cell culture studies show that the antioxidant thiol protein, thioredoxin-1 (Trx1), translocates to cell nuclei during stress, facilitates DNA binding of transcription factors NF-κB and glucocorticoid receptor (GR) and potentiates signaling in immune cells. Excessive proinflammatory signaling in vivo contributes to immune hyper-responsiveness and disease severity, but no studies have addressed whether nuclear Trx1 mediates such responses.

DOI: 10.1371/journal.pone.0018918
PubMed: 21526215


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

<record>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">Increased inflammatory signaling and lethality of influenza H1N1 by nuclear thioredoxin-1.</title>
<author>
<name sortKey="Go, Young Mi" sort="Go, Young Mi" uniqKey="Go Y" first="Young-Mi" last="Go">Young-Mi Go</name>
<affiliation wicri:level="2">
<nlm:affiliation>Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, Georgia, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, Georgia</wicri:regionArea>
<placeName>
<region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Kang, Sang Moo" sort="Kang, Sang Moo" uniqKey="Kang S" first="Sang-Moo" last="Kang">Sang-Moo Kang</name>
</author>
<author>
<name sortKey="Roede, James R" sort="Roede, James R" uniqKey="Roede J" first="James R" last="Roede">James R. Roede</name>
</author>
<author>
<name sortKey="Orr, Michael" sort="Orr, Michael" uniqKey="Orr M" first="Michael" last="Orr">Michael Orr</name>
</author>
<author>
<name sortKey="Jones, Dean P" sort="Jones, Dean P" uniqKey="Jones D" first="Dean P" last="Jones">Dean P. Jones</name>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PubMed</idno>
<date when="2011">2011</date>
<idno type="RBID">pubmed:21526215</idno>
<idno type="pmid">21526215</idno>
<idno type="doi">10.1371/journal.pone.0018918</idno>
<idno type="wicri:Area/PubMed/Corpus">000634</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000634</idno>
<idno type="wicri:Area/PubMed/Curation">000632</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000632</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000626</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000626</idno>
<idno type="wicri:Area/Ncbi/Merge">000449</idno>
<idno type="wicri:Area/Ncbi/Curation">000449</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000449</idno>
<idno type="wicri:Area/Main/Merge">001542</idno>
<idno type="wicri:Area/Main/Curation">001540</idno>
<idno type="wicri:Area/Main/Exploration">001540</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en">Increased inflammatory signaling and lethality of influenza H1N1 by nuclear thioredoxin-1.</title>
<author>
<name sortKey="Go, Young Mi" sort="Go, Young Mi" uniqKey="Go Y" first="Young-Mi" last="Go">Young-Mi Go</name>
<affiliation wicri:level="2">
<nlm:affiliation>Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, Georgia, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, Georgia</wicri:regionArea>
<placeName>
<region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Kang, Sang Moo" sort="Kang, Sang Moo" uniqKey="Kang S" first="Sang-Moo" last="Kang">Sang-Moo Kang</name>
</author>
<author>
<name sortKey="Roede, James R" sort="Roede, James R" uniqKey="Roede J" first="James R" last="Roede">James R. Roede</name>
</author>
<author>
<name sortKey="Orr, Michael" sort="Orr, Michael" uniqKey="Orr M" first="Michael" last="Orr">Michael Orr</name>
</author>
<author>
<name sortKey="Jones, Dean P" sort="Jones, Dean P" uniqKey="Jones D" first="Dean P" last="Jones">Dean P. Jones</name>
</author>
</analytic>
<series>
<title level="j">PloS one</title>
<idno type="eISSN">1932-6203</idno>
<imprint>
<date when="2011" type="published">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Animals</term>
<term>Antioxidants (metabolism)</term>
<term>Apoptosis (drug effects)</term>
<term>Cell Nucleus (drug effects)</term>
<term>Cell Nucleus (metabolism)</term>
<term>Cytokines (metabolism)</term>
<term>Gene Expression Regulation (drug effects)</term>
<term>Glucocorticoids (pharmacology)</term>
<term>Glutathione Disulfide (blood)</term>
<term>Humans</term>
<term>Inflammation (complications)</term>
<term>Inflammation (pathology)</term>
<term>Influenza A Virus, H1N1 Subtype (drug effects)</term>
<term>Influenza A Virus, H1N1 Subtype (physiology)</term>
<term>Influenza, Human (complications)</term>
<term>Influenza, Human (metabolism)</term>
<term>Influenza, Human (mortality)</term>
<term>Influenza, Human (virology)</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Transgenic</term>
<term>NF-kappa B (metabolism)</term>
<term>Nuclear Localization Signals (metabolism)</term>
<term>Orthomyxoviridae Infections (complications)</term>
<term>Orthomyxoviridae Infections (mortality)</term>
<term>Orthomyxoviridae Infections (pathology)</term>
<term>Orthomyxoviridae Infections (virology)</term>
<term>Oxidation-Reduction (drug effects)</term>
<term>Protein Transport (drug effects)</term>
<term>RNA, Messenger (genetics)</term>
<term>RNA, Messenger (metabolism)</term>
<term>Signal Transduction (drug effects)</term>
<term>Thioredoxins (genetics)</term>
<term>Thioredoxins (metabolism)</term>
<term>Weight Loss</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>ARN messager (génétique)</term>
<term>ARN messager (métabolisme)</term>
<term>Animaux</term>
<term>Antioxydants (métabolisme)</term>
<term>Apoptose ()</term>
<term>Cytokines (métabolisme)</term>
<term>Disulfure de glutathion (sang)</term>
<term>Facteur de transcription NF-kappa B (métabolisme)</term>
<term>Glucocorticoïdes (pharmacologie)</term>
<term>Grippe humaine ()</term>
<term>Grippe humaine (mortalité)</term>
<term>Grippe humaine (métabolisme)</term>
<term>Grippe humaine (virologie)</term>
<term>Humains</term>
<term>Infections à Orthomyxoviridae ()</term>
<term>Infections à Orthomyxoviridae (anatomopathologie)</term>
<term>Infections à Orthomyxoviridae (mortalité)</term>
<term>Infections à Orthomyxoviridae (virologie)</term>
<term>Inflammation ()</term>
<term>Inflammation (anatomopathologie)</term>
<term>Noyau de la cellule ()</term>
<term>Noyau de la cellule (métabolisme)</term>
<term>Oxydoréduction ()</term>
<term>Perte de poids</term>
<term>Régulation de l'expression des gènes ()</term>
<term>Signaux de localisation nucléaire (métabolisme)</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Souris transgéniques</term>
<term>Sous-type H1N1 du virus de la grippe A ()</term>
<term>Sous-type H1N1 du virus de la grippe A (physiologie)</term>
<term>Thiorédoxines (génétique)</term>
<term>Thiorédoxines (métabolisme)</term>
<term>Transduction du signal ()</term>
<term>Transport de protéines ()</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en">
<term>Glutathione Disulfide</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en">
<term>RNA, Messenger</term>
<term>Thioredoxins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en">
<term>Antioxidants</term>
<term>Cytokines</term>
<term>NF-kappa B</term>
<term>Nuclear Localization Signals</term>
<term>RNA, Messenger</term>
<term>Thioredoxins</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr">
<term>Infections à Orthomyxoviridae</term>
<term>Inflammation</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en">
<term>Inflammation</term>
<term>Influenza, Human</term>
<term>Orthomyxoviridae Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en">
<term>Apoptosis</term>
<term>Cell Nucleus</term>
<term>Gene Expression Regulation</term>
<term>Influenza A Virus, H1N1 Subtype</term>
<term>Oxidation-Reduction</term>
<term>Protein Transport</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr">
<term>ARN messager</term>
<term>Thiorédoxines</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en">
<term>Cell Nucleus</term>
<term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en">
<term>Influenza, Human</term>
<term>Orthomyxoviridae Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr">
<term>Grippe humaine</term>
<term>Infections à Orthomyxoviridae</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr">
<term>ARN messager</term>
<term>Antioxydants</term>
<term>Cytokines</term>
<term>Facteur de transcription NF-kappa B</term>
<term>Grippe humaine</term>
<term>Noyau de la cellule</term>
<term>Signaux de localisation nucléaire</term>
<term>Thiorédoxines</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en">
<term>Inflammation</term>
<term>Orthomyxoviridae Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr">
<term>Glucocorticoïdes</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en">
<term>Glucocorticoids</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr">
<term>Sous-type H1N1 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en">
<term>Influenza A Virus, H1N1 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr">
<term>Disulfure de glutathion</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr">
<term>Grippe humaine</term>
<term>Infections à Orthomyxoviridae</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en">
<term>Influenza, Human</term>
<term>Orthomyxoviridae Infections</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Animals</term>
<term>Humans</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Transgenic</term>
<term>Weight Loss</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Animaux</term>
<term>Apoptose</term>
<term>Grippe humaine</term>
<term>Humains</term>
<term>Infections à Orthomyxoviridae</term>
<term>Inflammation</term>
<term>Noyau de la cellule</term>
<term>Oxydoréduction</term>
<term>Perte de poids</term>
<term>Régulation de l'expression des gènes</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Souris transgéniques</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Transduction du signal</term>
<term>Transport de protéines</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">Cell culture studies show that the antioxidant thiol protein, thioredoxin-1 (Trx1), translocates to cell nuclei during stress, facilitates DNA binding of transcription factors NF-κB and glucocorticoid receptor (GR) and potentiates signaling in immune cells. Excessive proinflammatory signaling in vivo contributes to immune hyper-responsiveness and disease severity, but no studies have addressed whether nuclear Trx1 mediates such responses.</div>
</front>
</TEI>
<affiliations>
<list>
<country>
<li>États-Unis</li>
</country>
<region>
<li>Géorgie (États-Unis)</li>
</region>
</list>
<tree>
<noCountry>
<name sortKey="Jones, Dean P" sort="Jones, Dean P" uniqKey="Jones D" first="Dean P" last="Jones">Dean P. Jones</name>
<name sortKey="Kang, Sang Moo" sort="Kang, Sang Moo" uniqKey="Kang S" first="Sang-Moo" last="Kang">Sang-Moo Kang</name>
<name sortKey="Orr, Michael" sort="Orr, Michael" uniqKey="Orr M" first="Michael" last="Orr">Michael Orr</name>
<name sortKey="Roede, James R" sort="Roede, James R" uniqKey="Roede J" first="James R" last="Roede">James R. Roede</name>
</noCountry>
<country name="États-Unis">
<region name="Géorgie (États-Unis)">
<name sortKey="Go, Young Mi" sort="Go, Young Mi" uniqKey="Go Y" first="Young-Mi" last="Go">Young-Mi Go</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/StressCovidV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001540 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001540 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    StressCovidV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:21526215
   |texte=   Increased inflammatory signaling and lethality of influenza H1N1 by nuclear thioredoxin-1.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:21526215" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a StressCovidV1 

Wicri

This area was generated with Dilib version V0.6.33.
Data generation: Wed May 6 16:44:09 2020. Site generation: Sun Mar 28 08:26:57 2021